Human - Bigbrain at 400 μm, with coronal zoom at 20 μm.

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About this atlas

BigBrain is a high-resolution 3D digital atlas of the human brain, resulting from a joint effort of the Montreal Neurological Institute and the Forschungszentrum Jülich. It was released in June 2013 as part of the European Human Brain Project.

It consists of 7,404 coronal sections, each 20 µm thick, silver stained using the Merker method that darkens neuronal cell bodies. The slices have been digitized at 20 µm resolution and reconstructed back into a volume, thereby correcting for tears, shifts and deformations.

The region parcellation shown here is a very coarse mapping of the JuBrain atlas to the BigBrain template. It is by no means accurate and only intended for quick navigation.

This Scalable Brain Atlas template shows a 400 µm downsampled version of the Bigbrain data. The Microdraw plugin provides access to 20 µm sections, spaced 1200 µm apart. The full set of 20 µm isotropic data are available at bigbrain.loris.ca.

The defining citations for this atlas template are:

1. Amunts K, Lepage C, Borgeat L, Mohlberg H, Dickscheid T, Rousseau MÉ, Bludau S, Bazin PL, Lewis LB, Oros-Peusquens AM, Shah NJ, Lippert T, Zilles K, Evans AC (2013) "BigBrain: an ultrahigh-resolution 3D human brain model." Science 340(6139):1472-5. [doi 10.1126/science.1235381]

• silver stain: BigBrain silver stain (Merker) volume, converted to 8-bit grayscale, downsampled to 400μm.
  • ../BIGB13/source/full8_400um.nii.gz; filesize 23601 kB; shape [348x385x303]
  • ../BIGB13/source/full8_400um_downsample2.nii.gz; filesize 4048 kB; shape [174x192x151]
• colin27-T1: Colin27, average of 27 T1 scans of same individual, nonlinearly registered to BIGB13.
  • ../BIGB13/source/result.nii.gz; filesize 7224 kB; shape [348x385x303]
• tissue: BigBrain tissue classification 2013, downsampled to 400μm.
  • ../BIGB13/source/full_cls_400um.nii.gz; filesize 2949 kB; shape [348x386x303]
  • ../BIGB13/source/full_cls_400um_downsample2.nii.gz; filesize 528 kB; shape [174x193x151]
• coronal_svg: Coronal sections of the label volume "result", converted to Scalable Vector Graphics.
  Brain regions are color-coded by the RGB to Acronym map, which can be chained with the Acronym to Fullname map.
  • ../BIGB13/source/coronal_svg.zip; filesize 3473 kB